Class AlignerHelper
java.lang.Object
org.biojava.nbio.alignment.routines.AlignerHelper
Static utility to construct alignment routines from a common library of methods.
- Author:
- Mark Chapman, Daniel Cameron
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Nested Class Summary
Modifier and TypeClassDescriptionstatic class
Compounds in query and target sequences that must alignstatic class
Defines a 'cut' row for divide-and-conquer alignment in which a new anchor is found.static enum
Define a traceback pointer for the three edit operations: substitution (match/replacement of a query compound with a target compound), deletion (removal of a query compound leaving a gap in the target sequence), and insertion (addition of a target compound opening a gap in the query sequence).static class
Alignment subproblem. -
Constructor Summary
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Method Summary
Modifier and TypeMethodDescriptionstatic int
addAnchors
(AlignerHelper.Cut[] cuts, int[] scores, boolean addScore, int[] anchors) static AlignerHelper.Cut[]
getCuts
(int k, AlignerHelper.Subproblem subproblem, int[] dim, boolean anchor0) static void
setCuts
(int x, AlignerHelper.Subproblem subproblem, AlignerHelper.Last[][] pointers, AlignerHelper.Cut[] cuts) static AlignerHelper.Last
setScorePoint
(int x, int y, int gep, int sub, int[][][] scores) Calculates the optimal alignment score for the given sequence positions and a linear gap penaltystatic AlignerHelper.Last[]
setScorePoint
(int x, int y, int gop, int gep, int sub, int[][][] scores) Calculate the optimal alignment score for the given sequence positions with an affine or constant gap penaltystatic AlignerHelper.Last[][]
setScoreVector
(int x, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequence for a linear gap penaltystatic AlignerHelper.Last[][]
setScoreVector
(int x, int gop, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequencestatic AlignerHelper.Last[][]
setScoreVector
(int x, int xb, int yb, int ye, int gep, int[] subs, boolean storing, int[][][] scores, boolean startAnchored) Score global alignment for a given position in the query sequence for a linear gap penaltystatic AlignerHelper.Last[][]
setScoreVector
(int x, int xb, int yb, int ye, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequence for a linear gap penaltystatic AlignerHelper.Last[][]
setScoreVector
(int x, int xb, int yb, int ye, int gop, int gep, int[] subs, boolean storing, int[][][] scores, boolean startAnchored) Score global alignment for a given position in the query sequencestatic AlignerHelper.Last[][]
setScoreVector
(int x, int xb, int yb, int ye, int gop, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequencestatic AlignerHelper.Last[][]
setScoreVector
(int x, AlignerHelper.Subproblem subproblem, int gep, int[] subs, boolean storing, int[][][] scores) Score global alignment for a given position in the query sequence for a linear gap penaltystatic AlignerHelper.Last[][]
setScoreVector
(int x, AlignerHelper.Subproblem subproblem, int gop, int gep, int[] subs, boolean storing, int[][][] scores) Score global alignment for a given position in the query sequencestatic int[]
setSteps
(AlignerHelper.Last[][][] traceback, boolean local, int[] xyMax, AlignerHelper.Last last, List<AlignedSequence.Step> sx, List<AlignedSequence.Step> sy) Find alignment path through traceback matrixstatic int[]
setSteps
(AlignerHelper.Last[][][] traceback, int[][][] scores, List<AlignedSequence.Step> sx, List<AlignedSequence.Step> sy) Find global alignment path through traceback matrixstatic int[]
setSteps
(AlignerHelper.Last[][][] traceback, int[] xyMax, List<AlignedSequence.Step> sx, List<AlignedSequence.Step> sy) Find local alignment path through traceback matrixstatic String
tracebackToString
(AlignerHelper.Last[][][] traceback)
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Constructor Details
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AlignerHelper
public AlignerHelper()
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Method Details
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addAnchors
public static int addAnchors(AlignerHelper.Cut[] cuts, int[] scores, boolean addScore, int[] anchors) -
getCuts
public static AlignerHelper.Cut[] getCuts(int k, AlignerHelper.Subproblem subproblem, int[] dim, boolean anchor0) -
setCuts
public static void setCuts(int x, AlignerHelper.Subproblem subproblem, AlignerHelper.Last[][] pointers, AlignerHelper.Cut[] cuts) -
setScorePoint
public static AlignerHelper.Last[] setScorePoint(int x, int y, int gop, int gep, int sub, int[][][] scores) Calculate the optimal alignment score for the given sequence positions with an affine or constant gap penalty- Parameters:
x
- position in queryy
- position in targetgop
- gap opening penaltygep
- gap extension penaltysub
- compound match scorescores
- dynamic programming score matrix to fill at the given position- Returns:
- traceback direction for substitution, deletion and insertion
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setScorePoint
Calculates the optimal alignment score for the given sequence positions and a linear gap penalty- Parameters:
x
- position in queryy
- position in targetgep
- gap extension penaltysub
- compound match scorescores
- dynamic programming score matrix to fill at the given position- Returns:
- traceback directions for substitution, deletion and insertion respectively
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, AlignerHelper.Subproblem subproblem, int gop, int gep, int[] subs, boolean storing, int[][][] scores) Score global alignment for a given position in the query sequence- Parameters:
x
-subproblem
-gop
-gep
-subs
-storing
-scores
-- Returns:
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, int xb, int yb, int ye, int gop, int gep, int[] subs, boolean storing, int[][][] scores, boolean startAnchored) Score global alignment for a given position in the query sequence- Parameters:
x
-xb
-yb
-ye
-gop
-gep
-subs
-storing
-scores
-startAnchored
-- Returns:
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, AlignerHelper.Subproblem subproblem, int gep, int[] subs, boolean storing, int[][][] scores) Score global alignment for a given position in the query sequence for a linear gap penalty- Parameters:
x
-subproblem
-gep
-subs
-storing
-scores
-- Returns:
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, int xb, int yb, int ye, int gep, int[] subs, boolean storing, int[][][] scores, boolean startAnchored) Score global alignment for a given position in the query sequence for a linear gap penalty- Parameters:
x
-xb
-yb
-ye
-gep
-subs
-storing
-scores
-startAnchored
-- Returns:
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, int gop, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequence- Parameters:
x
-gop
-gep
-subs
-storing
-scores
-xyMax
-score
-- Returns:
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, int xb, int yb, int ye, int gop, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequence- Parameters:
x
-xb
-yb
-ye
-gop
-gep
-subs
-storing
-scores
-xyMax
-score
-- Returns:
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequence for a linear gap penalty- Parameters:
x
-gep
-subs
-storing
-scores
-xyMax
-score
-- Returns:
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setScoreVector
public static AlignerHelper.Last[][] setScoreVector(int x, int xb, int yb, int ye, int gep, int[] subs, boolean storing, int[][][] scores, int[] xyMax, int score) Score local alignment for a given position in the query sequence for a linear gap penalty- Parameters:
x
-xb
-yb
-ye
-gep
-subs
-storing
-scores
-xyMax
-score
-- Returns:
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setSteps
public static int[] setSteps(AlignerHelper.Last[][][] traceback, boolean local, int[] xyMax, AlignerHelper.Last last, List<AlignedSequence.Step> sx, List<AlignedSequence.Step> sy) Find alignment path through traceback matrix- Parameters:
traceback
-local
-xyMax
-last
-sx
-sy
-- Returns:
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setSteps
public static int[] setSteps(AlignerHelper.Last[][][] traceback, int[][][] scores, List<AlignedSequence.Step> sx, List<AlignedSequence.Step> sy) Find global alignment path through traceback matrix- Parameters:
traceback
-scores
-sx
-sy
-- Returns:
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setSteps
public static int[] setSteps(AlignerHelper.Last[][][] traceback, int[] xyMax, List<AlignedSequence.Step> sx, List<AlignedSequence.Step> sy) Find local alignment path through traceback matrix- Parameters:
traceback
-xyMax
-sx
-sy
-- Returns:
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tracebackToString
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